GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12304921 | 1 | rs67420027 | chr12:51349847 | SLC11A2 | chr12:51373319-51422058:- | -0.23 | -4.62 | 4.84E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs67420027 | chr12:51349847 | TFCP2 | chr12:51488608-51566917:- | -0.2 | -4.19 | 3.3E-5 | Type 2 diabetes |
| THCA | cis | rs6545883 | 1 | rs6742276 | chr2:61768745 | AHSA2 | chr2:61404553-61414058:+ | -0.23 | -9.33 | 3.86E-19 | Tuberculosis |
| THCA | cis | rs6545883 | 1 | rs6742276 | chr2:61768745 | C2orf74 | chr2:61372243-61391964:+ | 0.6 | 12.97 | 3.47E-33 | Tuberculosis |
| THCA | cis | rs6547705 | 1 | rs6743139 | chr2:87018452 | LOC285074 | chr2:87257799-87303536:- | -0.24 | -3.92 | 0.000103 | Progressive supranuclear palsy |
| THCA | cis | rs9346353 | 1 | rs67438720 | chr6:70475251 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.47 | 0.000574 | Sleep duration |
| THCA | cis | rs9371538 | 1 | rs67445790 | chr6:151876730 | C6orf97 | chr6:151815175-151942327:+ | 0.33 | 4.64 | 4.43E-6 | Bone mineral density (spine) |
| THCA | cis | rs9309473 | 1 | rs6745368 | chr2:73809974 | ALMS1P | chr2:73872046-73912692:+ | 0.76 | 11.69 | 6.08E-28 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6745368 | chr2:73809974 | NAT8 | chr2:73867850-73869537:- | 0.42 | 6.45 | 2.82E-10 | Metabolite levels |
| THCA | cis | rs607541 | 1 | rs674568 | chr15:45936587 | SPATA5L1 | chr15:45694519-45713614:+ | 0.3 | 4.98 | 8.85E-7 | Obesity-related traits |
| THCA | cis | rs3213787 | 1 | rs6746564 | chr2:45608409 | SRBD1 | chr2:45615820-45838433:- | -0.35 | -4.32 | 1.86E-5 | Glaucoma |
| THCA | cis | rs4332428 | 1 | rs67466576 | chr10:4977394 | AKR1C2 | chr10:4964715-5060207:- | 0.31 | 4.1 | 4.91E-5 | Height |
| THCA | cis | rs13191362 | 1 | rs67487119 | chr6:163102657 | PACRG | chr6:163148164-163736523:+ | 0.54 | 7.47 | 3.95E-13 | Body mass index |
| THCA | cis | rs6748734 | 1 | rs6748734 | chr2:241837452 | C2orf54 | chr2:241825466-241835573:- | 0.29 | 6.3 | 6.89E-10 | Urinary metabolites |
| THCA | cis | rs6547741 | 1 | rs6749052 | chr2:27772879 | FNDC4 | chr2:27714751-27718126:- | -0.15 | -3.51 | 0.000486 | Oral cavity cancer |